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佐々木拓哉のホームページ Takuya Sasaki's homepage


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*Corresponding Author, +Equal Contribution


Tohoku Univ, Prof (2021/7-)

100. K. Dewa, N. Arimura*, W. Kakegawa, M. Itoh, Y. T. Adachi, S. Miyashita, YU. Inoue, K. Hizawa, K. Hori, N. Honjoya, H. Yagishita, S. Taya, T. Miyazaki, C. Usui, S. Tatsumoto, A. Tsuzuki, H. Uetake, K. Sakai, K. Yamakawa, T. Sasaki, J. Nagai, Y. Kawaguchi, M. Sone, T. Inoue, Y. Go, N. Ichinohe, K. Kaibuchi, M. Watanabe, S. Koizumi, M. Yuzaki, M. Hoshino*
Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann Glia for the functional synapse formation
Nature Communications, 15:458, 2024.
doi:10.1038/s41467-023-44579-z

99. T. Okonogi, N. Kuga, M. Yamakawa, T. Kayama, Y. Ikegaya, T. Sasaki*
Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice
Nature Communications, 15(1):183, 2024.
doi:10.1038/s41467-023-44205-y
内容の詳細

98. N. Bénac, GE. Saraceno, C. Butler, N. Kuga, Y. Nishimura, T. Yokoi, P. Su, T. Sasaki, GR. Petit-PedrolM, V. Studer, F. Liu, Y. Ikegaya, J. Sibarita, L. Groc*
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis
Nature Communications, 15(1):27, 2024.
doi:10.1038/s41467-023-44301-z

96. T. Araki, T. Hiragi, N. Kuga, C. Luo, M. Andoh, K. Sugao, H. Nagata, T. Sasaki, Y. Ikegaya, R. Koyama*
Microglia induce auditory dysfunction after status epilepticus in mice
Glia, 72(2):274-288, 2023.
doi:10.1002/glia.24472

95. S. Yagi, H. Igata, Y. Ikegaya, T. Sasaki*
Awake hippocampal synchronous events are incorporated into offline neuronal reactivation
Cell Reports, 42:112871, 2023.
doi:10.1016/j.celrep.2023.112871

94. Y. Aoki, T. Yokoi, S. Morikawa, N. Kuga, Y. Ikegaya, T. Sasaki*
Effects of theta phase precessing optogenetic intervention on neuronal reactivation and spatial maps in the hippocampus
iScience, 26(7):107233, 2023.
doi:10.1016/j.isci.2023.107233

93. A. Cheng*, I. Kawahata, Y. Wang, W. Jia, H. Wang, T. Sekimori, Y. Chen, H. Suzuki, A. Takeda, N. Stefanova, D. Finkelstein, W. Ma, M. Chen, T. Sasaki*, K. Fukunaga*
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation
Brain, 146(8):3172-3180, 2023.
doi:10.1093/brain/awad137

92. A. Cheng*, W. Jia, D. Finkelstein, N. Stefanova, H. Wang, T. Sasaki T, I. Kawahata I, K. Fukunaga*
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model
Acta Pharmacologica Sinica, 45(1):66-75, 2023.
doi:10.1038/s41401-023-01138-y

88. M. Kudara, N. Kuga, K. Yamashiro, A. Yoshimoto, N. Matsumoto*, Y. Ikegaya*, T. Sasaki*
An open-source application to identify the three-dimensional locations of electrodes implanted into the rat brain from computed tomography images
Neuroscience Research, 193:20-27, 2023.
doi:10.1016/j.neures.2023.03.003

85. H. Wang, K. Fukunaga, A. Cheng, Y. Wang, N. Arimura, H. Yoshino, T. Sasaki, I. Kawahata*
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice
Journal of Pharmacological Sciences, 152(1):30-38, 2023.
doi:10.1016/j.jphs.2023.02.008

84. Y. Lu, X. Chen, X. Liu, Y. Shi, Z. Wei, L. Feng, Q. Jiang, W. Ye, T. Sasaki, K. Fukunaga, Y. Ji, F. Han, Y. Lu*
Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction
Autophagy, 1-18, 2023.
doi:10.1080/15548627.2022.2162244

82. DX. Sato, YU. Inoue, N. Kuga, S. Hattori, K. Nomoto, Y. Morimoto, G. Sala, H. Hagihara, T. Kikusui, T. Sasaki, Y. Ikegaya, T. Miyakawa, T. Inoue, M. Kawata*
Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety
iScience, 25(8): 104800, 2022.
doi:10.1016/j.isci.2022.104800

81. XX. Liu, XH. Chen, ZW. Zheng, Q. Jiang, C. Li, L. Yang, X. Chen, XF. Mao, HY. Yuan, LL. Feng, Q. Jiang, WX. Shi, T. Sasaki, K. Fukunaga, Z. Chen, F. Han, YM. Lu*
BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
Signal Transduction and Targeted Therapy, 7: 170, 2022.
doi:10.1038/s41392-022-00989-x

79. D. Konno, Y. Ikegaya, T. Sasaki*
Weak representation of awake/sleep states by local field potentials in aged mice
Scientific Reports, 12: 7766, 2022.
doi:10.1038/s41598-022-11888-0

78. E. Sugisawa, T. Kondo, Y. Kumagai, H. Kato, Y. Takayama, K. Isohashi, E. Shimosegawa, N. Takemura, Y. Hayashi, T. Sasaki, M. Martino, M. Tominaga, K. Maruyama*
Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
Cell Reports, 38: 110462, 2022.
doi:10.1016/j.celrep.2022.110462

77. Z. Li, X. Liu, C. Li, Z. Wei, Y. Shi, H. Song, X. Chen, Y. Zhang, J. Li, R. Zhu, B. HU, W. Ye, D. Huo, G. Jiang, T. Sasaki, L. Zhang, Y. Lu, F. Han*
Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelial CDK5-deficient mice
MedComm, 3(3): e128, 2022.
doi:10.1002/mco2.128

76. T. Kayama, Y. Ikegaya, T. Sasaki*
Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses
Scientific Reports, 12: 1447, 2022.
doi:10.1038/s41598-022-05306-8



Tokyo Univ, Associate Prof (2020/7-2021/6)

74. Y. Nishimura, Y. Ikegaya, T. Sasaki*
Concurrent recordings of hippocampal neuronal spikes and prefrontal synaptic inputs from an awake rat
STAR Protocols, 2: 100572, 2021.
doi:10.1016/j.xpro.2021.100572

70. S. Iwasaki, T. Sasaki, Y. Ikegaya*
Hippocampal beta oscillations predict mouse object-location associative memory performance
Hippocampus, 31: 503-511, 2021
doi:10.1073/pnas.2011266118

67. H. Yagishita, Y. Nishimura, A. Noguchi, Y. Shikano, Y. Ikegaya, T. Sasaki*
Urethane anesthesia suppresses hippocampal subthreshold activity and neuronal synchronization
Brain Research, 1749: 147137, 2020.
doi:10.1016/j.brainres.2020.147137


Tokyo Univ, Assist Prof (2014/10-2020/6)

65. N. Kuga, R. Nakayama, Y. Shikano, Y. Nishimura, T. Okonogi, Y. Ikegaya, T. Sasaki*
Sniffing behavior-related changes in cardiac and cortical activity in rats
Journal of Physiology, 597: 5295-5306, 2019.
doi:10.1113/JP278500

64. R. Nakayama, Y. Ikegaya, T. Sasaki*
Cortical-wide functional correlations are associated with stress-induced cardiac dysfunctions in individual rats
Scientific Reports, 9: 10581, 2019.
doi:10.1038/s41598-019-47171-y

58. Y. Kasahara+, H. Igata+, T. Sasaki, Y. Ikegaya, R. Koyama*
The pharmacological assessment of GABAA receptor activation in experimental febrile seizures in mice
eNeuro, 6, 2019.
doi:10.1523/ENEURO.0429-18.2019

57. T. Kayama, K. Okamoto, M. Gao, Y. Ikegaya, T. Sasaki*
Immature electrophysiological properties of human-induced pluripotent stem cell-derived neurons transplanted into the mouse cortex for seven weeks
Neuroreport, 30: 169-173, 2019.
doi:10.1097/WNR.0000000000001178

52. S. Yagi, H. Igata, Y. Shikano, Y. Aoki, T. Sasaki*, Y. Ikegaya
Time-varying synchronous cell ensembles during consummatory periods correlate with variable numbers of place cell spikes.
Hippocampus, 28: 471-483, 2018.
doi:10.1002/hipo.22846

51. T. Okonogi, R. Nakayama, T. Sasaki*, Y. Ikegaya
Characterization of peripheral activity states and cortical local field potentials of mice in an elevated plus maze test.
Frontiers in Behavioral Neuroscience, 12: 62, 2018.
doi:10.3389/fnbeh.2018.00062

50. Y. Shikano, Y. Ikegaya, T. Sasaki*
Monitoring brain sneuronal activity with manipulation of cardiac events in a freely moving rat.
Neuroscience Research, 136: 56-62, 2018.
doi:10.1016/j.neures.2018.02.004

49. H. Norimoto, K. Makino, M. Gao, Y. Shikano, K. Okamoto, T. Ishikawa, T. Sasaki, H. Hioki, S. Fujisawa*, Y. Ikegaya*
Hippocampal ripples down-regulate synapses.
Science, 359: 1524-1527, 2018.
doi:10.1126/science.aao0702

46. Y. Shikano, T. Sasaki*, Y. Ikegaya
Simultaneous recordings of cortical local field potentials, electrocardiogram, electromyogram, and breathing rhythm from a freely moving rat.
Journal of Visualized Experiments, 134, 2018.
doi:10.3791/56980

44. Y. Aoki, Y. Nishimura, T. Hondrich, R. Nakayama, H. Igata, T. Sasaki*, Y. Ikegaya*
Selective attenuation of electrophysiological activity of the dentate gyrus in a social defeat mouse model.
Journal of Physiological Sciences, 67: 507-513, 2017.
doi:10.1007/s12576-016-0481-0

42. Y. Nishimura, R. Abe, T. Sasaki*, Y. Ikegaya*
Homeostatic changes in neuronal network oscillations in response to continuous hypoperfusion in the mouse forebrain.
Neuroscience Research, 109:28-34, 2016.
doi:10.1016/j.neures.2016.02.007

39. S. Ujita, T. Sasaki, A. Asada, K. Funayama, M. Gao, K. Mikoshiba, N. Matsuki, Y. Ikegaya*
cAMP-dependent Calcium Oscillations of Astrocytes: An Implication for Pathology.
Cerebral Cortex, 27: 1602-1614, 2017.
doi:10.1093/cercor/bhv310


UCSD, Postdoc (2013/2-2014/09)

37. H. Sanders*, D. Ji, T. Sasaki, JK. Leutgeb, M. Wilson, JE. Lisman
Temporal coding and rate remapping: representation of non-spatial information in the hippocampus.
Hippocampus, 29: 111-127, 2019.
doi:10.1002/hipo.23020

36. T. Sasaki+, VC. Piatti+, E. Hwaun, S. Ahmadi, JE. Lisman, S. Leutgeb, JK. Leutgeb*
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons.
Nature Neuroscience, 21: 258-269, 2018.
doi:10.1038/s41593-017-0061-5
内容の詳細

34. T. Sasaki*
Probing neuronal activity using genetically encoded red fluorescent calcium indicators.
Optogenetics-Light-sensing proteins and their applications- (Springer), 149-158, 2015.


Tokyo Univ, Postdoc (2010/4-2014/6)

33. T. Sasaki*, T. Ishikawa, R. Abe, R. Nakayama, A. Asada, N. Matsuki, Y. Ikegaya
Astrocyte calcium signaling orchestrates neuronal synchronization in organotypic hippocampal slices.
Journal of Physiology, 592: 2771-2783, 2014.
doi:10.1113/jphysiol.2014.272864

31. C. Kobayashi, M. Ohkura, J. Nakai, N. Matsuki, Y. Ikegaya, T. Sasaki*
Large-scale imaging of subcellular calcium dynamics of cortical neurons with GCaMP6-actin.
Neuroreport, 25: 501-506, 2014.
doi:10.1097/WNR.0000000000000126

26. Y. Ikegaya*+, T. Sasaki+, D. Ichikawa+, N. Honma+, K. Tao, G. Minamisawa, N. Takahashi, S. Ujita, N. Matsuki Inter-pyramid spike transmission stabilizes the sparseness of recurrent network activity.
Cerebral Cortex, 24: 293-304, 2013.
doi:10.1093/cercor/bhs006

25. R.Koyama*, K. Tao+, T. Sasaki+, J. Ichikawa, D. Miyamoto, R. Muramatsu, N. Matsuki, Y. Ikegaya
GABAA receptors regulate ectopic granule cell migration and development of epilepsy after experimental febrile seizures in the rat.
Nature Medicine, 18: 1271-1278, 2012.
doi:10.1038/nm.2850

24. Y. Okada*, T. Sasaki, Y. Oku, N. Takahashi, M. Seki, S. Ujita, K. Tanaka, N. Matsuki, Y. Ikegaya
Preinspiratory calcium rise in putative pre-Bötzinger complex astrocytes.
Journal of Physiology, 590: 4933-4944, 2012.
doi:10.1113/jphysiol.2012.231464


NIPS, Postdoc (2011/4-2013/3)

23. K. Kanemaru, H. Sekiya, M. Xu, K. Satoh, N. Kitajima, K. Yoshida, Y. Okubo, T. Sasaki, S. Moritoh, H. Hasuwa, M. Mimura, K. Horikawa, K. Matsui, T. Nagai, M. Iino, KF. Tanaka*
In vivo visualization of subtle, transient and local activity of astrocytes using an ultrasensitive Ca2+ indicator.
Cell Reports, 8, 311-318, 2014.
doi:10.1016/j.celrep.2014.05.056

22. K. Beppu+, T. Sasaki+, KF. Tanaka, A. Yamanaka, Y. Fukazawa, R. Shigemoto, K. Matsui*
Optogenetic countering of glial acidosis supressees glial glutamate release and ischemic brain damage.
Neuron, 81, 314-320, 2014.
doi:10.1016/j.neuron.2013.11.011
内容の詳細

20. KF. Tanaka+*, K. Matsui+*, T. Sasaki, H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, M. Okabe, K. Deisseroth, A. Yamanaka
Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system.
Cell Reports, 2: 397-406, 2012.
doi:10.1016/j.celrep.2012.06.011


Saitama Univ, Postdoc (2010/4-2011/3)

19. M. Ohkura+*, T. Sasaki+, J. Sadakari, K. Gengyo-Ando, Y. Kagawa-Nagamura, C. Kobayashi, Y. Ikegaya*, J. Nakai*
Genetically encoded green fluorescent Ca2+ indicators with improved detectability for neuronal Ca2+ signals.
PLoS ONE, 7: e51286, 2012.
doi:10.1371/journal.pone.0051286

18. M. Ohkura+*, T. Sasaki+, C. Kobayashi, Y. Ikegaya, J. Nakai*
An improved genetically encoded red fluorescent Ca2+ indicator for detecting optically evoked action potentials.
PLoS ONE, 7: e39933, 2012.
doi:10.1371/journal.pone.0039933


Tokyo Univ, Doctor Student (2007/4-2010/3)

11. D. Ishikawa, N. Takahashi, T. Sasaki, A. Usami, N. Matsuki, Y. Ikegaya*
Fluorescent pipettes for optically targeted patch-clamp recordings.
Neural Networks, 23: 669-672, 2010.
doi:10.1016/j.neunet.2010.02.004

9. A. Usami, T. Sasaki, N. Satoh, T. Akiba, S. Yokoshima, T. Fukuyama, K. Yamatsugu, M. Kanai, M. Shibasaki, N. Matsuki, Y. Ikegaya*
Oseltamivir enhances hippocampal network synchronization.
Journal of Pharmacological Science, 106: 659-662, 2008.
doi:10.1254/jphs.sc0070467


Tokyo Univ, Master Student (2005/4-2007/3)

5. T. Sasaki, R. Kimura, M. Tsukamoto, N. Matsuki, Y. Ikegaya*
Integrative spike dynamics of rat CA1 neurons: a multineuronal imaging study.
Journal of Physiology, 574: 283-290, 2006.
doi:10.1113/jphysiol.2006.108480

4. R. Koyama, R. Muramatsu, T. Sasaki, R. Kimura, C. Ueyama, M. Tamura, N. Tamura, J. Ichikawa, N. Takahashi, A. Usami, M.K Yamada, N. Matsuki, Y. Ikegaya*
A low-cost method for brain slice cultures.
Journal of Pharmacological Science, 104: 191-194, 2007.
doi:10.1254/jphs.sc0070119

3. M. Tsukamoto-Yasui, T. Sasaki, W. Matsumoto, A. Hasegawa, T. Toyoda, A. Usami, Y. Kubota, T. Ochiai, T. Hori, N. Matsuki, Y. Ikegaya*
Active hippocampal networks undergo spontaneous synaptic modification.
PLoS ONE, 11: e1250, 2007.
doi:10.1371/journal.pone.0001250


Tohoku Univ, Undergraduate (2004/4-2005/3)

1. T. Sasaki+, F. Han+, K. Ishiguro, N. Shioda, S. Moriguchi, J. Kasahara, K. Fukunaga*
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Brain Research, 1108: 98-106, 2006.
doi:10.1016/j.brainres.2006.06.009



その他 和文など


*論文責任著者

28. *佐々木拓哉
内受容感覚を伝達する経路と脳情報処理
実験医学 2023年

27. 久我奈穂子、*佐々木拓哉
学習時の個性
生体の科学 第75巻1号 2023年

26. *佐々木拓哉
内臓信号が神経回路演算に及ぼす影響の考察
神経回路学会誌 2023年

25. *佐々木拓哉
求心性迷走神経を介した脳末梢連環の意義
ファルマシア, 最前線 2023年

24. *佐々木拓哉
最新脳科学と応用(5) ~学習・記憶・意思決定~
Yano E plus 4月号, 2023年

23. 鹿野悠、*佐々木拓哉、池谷裕二
齧歯目における分オーダーの時間認知
CLINICAL NEUROSCIENCE 41:1055-1058, 2023年

22. *佐々木拓哉
研究室紹介:薬学の学生と神経科学を楽しむ
神経科学ニュース 2022年1月号 2022年3月

21. 郭青云、川畑伊知郎、*佐々木拓哉、福永浩司
脳虚血性細胞死における脂肪酸結合タンパク質(FABP)の役割
脳循環代謝(Web) 33(1) 2021年

20. *佐々木拓哉
実験動物における迷走神経の光遺伝学的操作
自律神経 第58号125-132 2021年3月

19. *佐々木拓哉
脳回路動態をとシナプスレベルで理解する研究
月刊「アグリバイオ」2020年2月号

18. 大内彩子、*佐々木拓哉、池谷裕二
海馬神経同期発火の生理的意義に関する最近の知見
月刊「細胞」 2019年

17. 中山亮太、池谷裕二、*佐々木拓哉
末梢臓器動態に基づく動物の精神状態の評価
日本薬理学雑誌153巻4号 2019年4月

16. *佐々木拓哉
神経回路とシナプス動態を繋ぐ研究の一例
月刊「細胞」50巻14号 2018年12月

15. *佐々木拓哉
作業記憶を担う海馬および歯状回による神経機構
ライフサイエンス新着論文レビュー 2018年1月

14.鹿野悠、*佐々木拓哉、池谷裕二
海馬神経細胞の時間表象
Brain and Nerve, 69: 1233-1239, 2018.

13.八幡洋輔、*佐々木拓哉
動物の個性を考慮した行動解析
日本薬理学雑誌150巻2号 2017年8月

12.*佐々木拓哉
海馬の場所細胞と病態研究
日本薬理学雑誌149巻5号 2017年5月

11.岡田桜、青木勇樹、*佐々木拓哉、池谷裕二
海馬研究の最前線
Brain and Nerve, 69: 453-460, 2017.

10.*佐々木拓哉
中枢末梢連関の理解に向けた生体電気信号の網羅的解析
日本薬理学雑誌149巻4号 2017年4月

9.青木勇樹、*佐々木拓哉
脳の基礎研究から精神疾患の標的を探る
薬事日報 2015年12月28日号

8.*佐々木拓哉
脳内での空間認知メカニズムを解明!自分の居場所を認識する神経細胞の発見(ノーベル賞解説記事)
月刊化学 第69巻2014年12月号

7.*佐々木拓哉
2014年ノーベル生理学・医学賞:脳内の空間表象を司る神経細胞の発見(ノーベル賞解説記事)
実験医学 第32巻19号2014年12月号

6.*佐々木拓哉
記憶のメカニズムに光を当てる最先端の生理学研究ツール
実験医学 第32巻8号2014年4月

5.*佐々木拓哉
解析の生理学
日本生理学雑誌 第76巻1号 2014年1月

4.*佐々木拓哉
リレーエッセイ
日本薬理学雑誌138巻5号 2011年11月

3. *佐々木拓哉
オプトジェネティクス ~光工学と遺伝子による行動制御技術の最前線~ 2013年4月

2. 佐々木拓哉、*池谷裕二
活動電位は軸索の伝導中に制御される
ライフサイエンス新着論文レビュー 2011年2月

1.佐々木拓哉、高橋直矢、宇佐美篤、*池谷裕二
Multineuronal calcium imaging(MCI) ─ 多ニューロン活動を可視化して脳ネットワーク機能を解明する
日本薬学会ビジョン部会誌 2006年11月号